Experiments on cell proliferation and metaplasia by Charles Powell White

Cover of: Experiments on cell proliferation and metaplasia | Charles Powell White

Published by s.n. in [S.l .

Written in English

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Subjects:

  • Cell proliferation.,
  • Metaplasia.

Edition Notes

Cover title.

Book details

Statementby Charles Powell White.
The Physical Object
Paginationp. [450]-462, XXIX [i.e. 5] leaves of plates :
Number of Pages462
ID Numbers
Open LibraryOL20268966M

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The phenomenon of metaplasia Definitions and explanations. Metaplasia means the conversion of one cell type to another during postnatal life and includes the conversion of tissue-specific stem cells.The explanation for metaplasia lies in understanding the normal developmental biology of the cells that by: Metaplasia is defined as the conversion of one cell type to another and can include conversions between tissue-specific stem cells.1,2 Transdifferentiation, on the other hand, refers to the conversion of one differentiated cell type to another 3,4 and should therefore be considered a subset of metaplasia.

Historically, metaplasia has been the. Cell proliferation and apoptosis in gastric cancer and intestinal metaplasia Article (PDF Available) in Arquivos de Gastroenterologia 42(1) March with 43 Reads How we measure 'reads'. A neoplasm can be caused by an abnormal proliferation of tissues, which can be caused by genetic all types of neoplasms cause a tumorous overgrowth of tissue, however (such as leukemia or carcinoma in situ) and similarities between neoplasmic growths and regenerative processes, e.g., dedifferentiation and rapid cell proliferation, have been pointed lty: Oncology.

Cell proliferation is the increase in cell number as a result of cell division and growth. The process of cell proliferation depends on the prior occurrence of a series of internal cellular changes before either mitotic or meiotic division starts.

These changes occur in a given orderly sequence known as the four phase of the cell cycle, and. between toxicity (as quantified by the MTD) and carcinogenicity (as quantified by the TD 50) is consistent with cell toxicity and the resulting cell proliferation's mediating of the carcinogenicity observed in some animal r, the committee recognizes that other reasons for the observed relationship are possible.

Definition: Metaplasia is the reversible replacement of one differentiated cell type with another differentiated cell type. Metaplasia causes precursor cells to change their cell fate, and do not change existing differentiated cells. Metaplasia is reversible and usually occurs in response to chronic irritation and inflammation and allows for substitution of cells that are.

The cell of origin for intestinal metaplasia in the oesophagus and stomach and for pancreatic acinar–ductal metaplasia has been posited through genetic.

While some cell types, such as those that compose the skin and bone marrow, continue to proliferate throughout life, other types including bone and muscle cells cease active proliferation when a human reaches adulthood.

Most normal cells remain in a non-proliferative state unless they are stimulated to divide to replace lost cells. Abnormal regulation of the cell cycle can. Summary Cell Proliferation and Apoptosis provides a detailed practical guide to cell proliferation and apoptosis detection methods.A novel approach combining both these areas allows important comparisons to be made.

Topics covered include all aspects of tissue handling from collection, storage, fixation and processing through to locating and quantifying cells in different stages of.

pylori infection is now accepted as the cause of the most common form of chronic gastritis. It is also widely accepted that the infection is at least the triggering factor for, if not the direct cause of, atrophy and intestinal metaplasia.

These alterations in the gastric mucosa predispose to peptic ulceration. Given that they are maximal in the antrum-corpus TZ, this is the site of Cited by: Furthermore, gastric cell proliferation rates correlate with salt intake only when the subject is infected with H.

pylori (72, ), which could make the high salt-H. pylori combination particularly carcinogenic. Dietary vitamin C (ascorbic acid), on the other hand, is epidemiologically linked to lower rates of gastric carcinoma (31, ).Cited by: Until such experiments have been performed, it seems prudent to conclude that regeneration of lost β-cells generally involves expansion of those cells left behind, rather than neogenesis (see Figure 3A).

β-cell proliferation is known to accelerate under physiological conditions of high insulin demand, such as pregnancy, and this same.

squamous cell carcinoma of the cervix, cancer of the lung, malignant melanoma, renal cell carcinoma What are some cellular characteristics of anaplasia 1.

the cells and their nuclei are polymorphic (variation in size and shape). Cell proliferation is controlled by using growth factor (Fetal calf serum), Which normally bind to the surface receptors present on the cell membrane generally regulate the cell signaling molecules, which pass the message to nucleus by help of receptor generally where the transcription factor gets bind to the DNA, makes turn off turn on the.

In-vitro assays include proliferation, migration, invasion and flow cytometry to analyze cell cycle arrest. In in-vivo experiments, in addition to the expression analyses, we followed the preneoplastic lesions and the tumor progression by ultrasonography, endoscopy, biopsies, histopathology and : Amanda Braga Bona, Danielle Queiroz Calcagno, Helem Ferreira Ribeiro, José Augusto Pereira Carneiro.

Purchase Handbook of Stem Cells - 2nd Edition. Print Book & E-Book. ISBNCell proliferation is dynamic, measurement of it should include time, moreover it can even change with time. Therefore, one time point measurements are always equivocal, and even observations over time must neglect acceleration or slowing of proliferative activity, unless experiments are tremendous laborious with multiple time point by: 1.

A medical research team led by University of Miami doctors injected stem cells into the hearts of pigs that had been damaged by heart attacks.

Within two months, the doctors said, the stem cells. Lung – Metaplasia, Goblet Cell studies. Rats and mice have very low numbers of goblet (mucous) cells in their lungs. Under normal conditions, File Size: KB. Chapter 15—Assays for Cell Viability, Proliferation and Function Overview of Probes for Cell Viability, Cell Proliferation and Live-Cell Function—Section ; Viability and Cytotoxicity Assay Reagents—Section ; Viability and Cytotoxicity Assay Kits for.

Cdx2 has been suggested to play an important role in Barrett's esophagus or intestinal metaplasia (IM) in the esophagus. To investigate whether transgenic overexpression of cdx1b, the functional equivalent of mammalian Cdx2 in zebrafish, may lead to IM of zebrafish esophageal squamous epithelium, a transgenic zebrafish system was developed by expressing cdx1b gene under the.

Human hepatocarcinoma Hep3B cell line was purchased from American Type Culture Collection (ATCC) and maintained in our in-house National Cell Repository, National Centre for Cell Science (NCCS), Pune, India. Drug immune ringer was developed from and parental Hep3B cells by treated with bit by bit increasing concentrations of.

Metaplasia, in zoology, the conversion of one type of living cell or group of cells into another as a means of example, the damaged or removed lens of a salamander eye is replaced through the transformation of nearby pigmented iris cells into lens cells.

The regeneration of brain tissue from epidermis in annelid worms is another well-documented. Gastric cancer remains one of the leading causes of global cancer mortality.

It has been shown that gastric cancer may originate from adult gastric stem cells and that it contains a subpopulation of cancer cells with stem cell characteristics, which are linked to Helicobacter pylori infection, therapy resistance and metastasis.

Thus, the identification of transcription factors and related Author: Estefania Carrasco-Garcia, Mikel García-Puga, Manuel Moreno, Nicolas Sampron, Sara Arevalo, Ander Ma. Gastric stem cells have been recently identified and are not yet fully characterized. Each gastric gland or unit is composed of different specialized cells and a small number of discrete stem cells.

These gastric stem cells play key roles. They have self-renewal and multipotent properties and are the origin of specialized gastric epithelial cells. These properties are the basis for the stem Author: Julie Giraud, Emilie Bessède, Francis Mégraud, Christine Varon. Primary Myelofibrosis previously also known as Agnogenic Myeloid Metaplasia or Idiopathic Myelofibrosis is a complex myeloproliferative disease.

Although the initial genetic insult that causes uncontrolled proliferation of the defective Hematopoietic Stem Cell/Hematopoietic Progenitor Cell is still elusive, literature is being enriched with Cited by: 8. Start studying Cellular Response to Injury.

Learn vocabulary, terms, and more with flashcards, games, and other study tools. Search. Create. - cell proliferation Metaplasia is when one adult cell type is.

The primary effect of vitamin A deficiency is on epithelial structures. The sequences are atrophy of the epithelium concerned and the substitution for it of a stratified keratinizing epithelium, identical in appearance in all locations, and. The audience’s favorite diagnosis was exaggerated mucous cell metaplasia (60%), and this was Dr.

Rittinghausen’s choice as well. The diagnostic features of pulmonary mucous cell metaplasia were then presented to the audience (Table 13). Differential diagnoses of alveolar proteinosis, bronchiolo-alveolar hyperplasia, bronchial adenocarcinoma.

Jou said that PSPC1 not only promotes cancer cell proliferation, but it also turns regular cells into mobile cells, promotes cancer metastasis, and even develops cancer stem cells that cause tumors and build resistance against cancer treatment drugs. Metaplasia (Greek: "change in form") is the reversible replacement of one differentiated cell type with another mature differentiated cell type.

The change from one type of cell to another may generally be a part of normal maturation process or caused by some sort of abnormal stimulus. Abstract. The occurrence of cell death in neoplastic lesions has long been known.

Until recently, the type of cell death described in tumors was cell necrosis most probably resulting from the altered blood supply of the : G. Ledda-Columbano, P. Coni, M. Curto, P. Pani, D. Sarma, A. Columbano.

The impulse to write came because: there is neither book nor review article on chondroid bone; secondary cartilages have received only fragmentary attention since ; and metaplasia is a perennial challenge to the concept of differentiation which is seldom tackled in the round.

In the healthy endometrium, progesterone and estrogen signaling coordinate in a tightly regulated, dynamic interplay to drive a normal menstrual cycle and promote an embryo-receptive state to allow implantation during the window of receptivity. It is well-established that progesterone and estrogen act primarily through their cognate receptors to set off cascades of signaling Cited by: 6.

Androgens are essential for the development, differentiation, growth, and function of the prostate through epithelial–stromal interactions. However, androgen concentrations in the hypertrophic human prostate decrease significantly with age, suggesting an inverse correlation between androgen levels and proliferative diseases of the aging prostate.

In elderly males, age- and/or Cited by: 2. Both antisense morpholino oligonucleotide (MO)‐mediated knockdown and overexpression experiments were performed to analyze zebrafish cdx1b's function in intestinal cell ntial reductions in goblet cell numbers were detected in intestines of ‐ and ‐hours post‐fertilization (hpf) cdx1b MO‐injected embryos (morphants) compared to Cited by: Cell proliferation was measured using the Cell Proliferation Assay Kit (Millipore, USA), according to the manufacturer’s protocol in triplicate.

Briefly, 10µl of WST-1/ECS solution was added to each well, the samples were incubated for 4hr at standard culture conditions and absorbance was measured at nm. Cell viability were counted by. In the second trial, 25 female and 17 male volunteers were intermittently exposed to airborne acrolein for up to min at increasing concentrations—0,and ppm.

Questionnaires were provided to volunteers after 1 min of exposure. The volunteers were allowed 8 min of recovery in a well-ventilated room between successive. Metaplasia was present in 70% of male cigarette smokers.

Women in each category revealed half the frequency of metaplasia present in the men. Metaplasia was present in less than 20% of men under the age of 30 years, rose to a peak of 80% at age 50 years, and gradually declined in frequency after the age of 60 by: 8.

Moreover, Rap1A can reverse the effect of miRp mimic on cell proliferation, invasion, migration and apoptosis (all p Cited by: 1. We use your LinkedIn profile and activity data to personalize ads and to show you more relevant ads. You can change your ad preferences anytime.

The EIF4G1 and RhoA experiments were not performed in lung-derived cells (they were done in breast epithelial and fibroblast cell lines, respectively), however were used in the network construction process due to 1) the proximity of the perturbation used to modulate cell proliferation to the mechanisms which are known to occur in lung cells and Cited by:

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